Ginger as an Antinausea Agent: Part 3
Ginger has been recommended to combat nausea associated with chemotherapy. Gingerol was reported to reduce cisplatin (a platinum based chemotherapy drug)-induced emesis in a vomiting model of mink possibly by inhibiting the central or peripheral increase of 5-hydroxytryptamine, dopamine, and substance P. In contrast, addition of ginger root powder (1 g/day) to a standard antiemetic regimen with metoclopramide had no advantage in reducing nausea or vomiting in acute or delayed phases of cisplatin- induced emesis in gynecologic cancer patients. Cisplatin can cause renal oxidative and nitrosative stress and dysfunction. However, rats that were administered cisplatin and [6]-gingerol exhibited lower lipid peroxidation and conservation of GSH coupled with enhanced superoxide dismutase and catalase, which resulted in a restoration of normal renal function. Complementary intervention with ginger has also been suggested to have possible benefits in preventing acute chemotherapy-induced nausea and vomiting (CINV) in children.
However, the results of a randomized, double-blind, placebo-controlled trial indicated that ginger did not provide any additional benefit in reducing CINV when given with a 5-hydroxytryptamine 3 (HT3) receptor antagonist and/or aprepitant (a substance P antagonist). Notably, compared with a normal diet, high-protein meals with ginger consumed twice daily were reported to reduce the delayed nausea of chemotherapy and decrease the use of antiemetic medications.
According to the Australian relatives, some people who were challenged with cancer began taking this unusual sounding juice on the advice of someone local and they both found it to be very healing. Why purple carrot juice, we wondered, and if it was so great why didn’t everyone know about it? After a little digging, we found out that the purple version of the ubiquitous orange root vegetable fell out of favour many years ago – nearly a century, actually – and thus was no longer cultivated as widely as it once had been. For whatever reason, orange carrots became a fad some time ago and they have now become what we all think of when we think of carrots.
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